发明名称 |
Attack of tumor cells with missing, low or aberrant MHC expression by combining non MHC-restricted T-cells/NK-cells and MHC-restricted cells |
摘要 |
This invention is directed to therapeutic compositions containing non-MHC-restricted Tcells/NK-cells in combination with MHC-restricted T-cells and especially to therapeutic compositions, which comprise LAK cells. Furthermore, the present invention is directed to the use of the above combination in the treatment of tumors in humans, which tumors show a missing, low or aberrant expression of MHC class Ia or Ib molecules. By using the aforementioned compositions/combinations it is possible to provide a balanced selective pressure against emergence of tumor cell variants that would otherwise escape immune detection. |
申请公布号 |
US8142772(B2) |
申请公布日期 |
2012.03.27 |
申请号 |
US20100765234 |
申请日期 |
2010.04.22 |
申请人 |
NOESSNER ELFRIEDE;WEISS ELISABETH;SCHENDEL DOLORES;FALK CHRISTINE;HELMHOLTZ ZENTRUM MUNCHEN DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH) |
发明人 |
NOESSNER ELFRIEDE;WEISS ELISABETH;SCHENDEL DOLORES;FALK CHRISTINE |
分类号 |
A01N63/02;C12N5/06;A61K35/00;A61K35/12;A61K39/00;A61K45/00;A61K45/06;A61K48/00;A61P35/00;A61P43/00;C12N5/08 |
主分类号 |
A01N63/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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