发明名称 |
PEPTIDE AMIDATION PROCESS |
摘要 |
The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1- cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cystein is the first amino acid of a palladium cleavage site comprising the sequence cysteine-X2 - X3, wherein X2 is any amino acid, X3 is an amino acid selected from the group consisting of cysteine, histidine, or methionine, and wherein the carboxyl~terminus of the peptide is amidated upon cleavage at the Xl- cysteine sequence.
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申请公布号 |
CA2485698(C) |
申请公布日期 |
2012.03.27 |
申请号 |
CA20032485698 |
申请日期 |
2003.05.23 |
申请人 |
RESTORAGEN, INC. |
发明人 |
SEO, JIN SEOG;HOLMQUIST, BARTON;STRYDOM, DANIEL |
分类号 |
C12N15/09;C12P21/06;C07K1/00;C07K1/107;C07K5/103;C07K5/107;C07K5/113;C07K7/06;C07K7/08;C07K7/23;C07K14/575;C07K14/60;C07K14/615;C07K14/655;C07K14/665;C12N1/21 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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