| 摘要 |
(A) N-substd. 9-(aminoalkyl) 9,10-dihydro 9,10-ethano-anthracenes with the nucleus of formula (I) contng. a free- or acylated hydroxyl- or oxo group at pos. 12. The alkylene residue of the N-substd. aminoalkyl at pos. 9 is pref. a linear- or branched alkylene (C1-4). The amino group may be sec. or tert. and is pref. aliphatic such as an aliphatic hydrocarbon (max C8) opt. contng. hetero-atoms in the chain. They may be further substd. at pos. 1-8 with alkyl (max C6), alkoxy (max C8), halogen, trifluoromethyl and/or nitro; pref. not more than 2 substituents each at pos. 1-4 and 5-8. Pos. 11 or 12 may be substd. with alkyl, pref. methyl. Preferred cpds. (I) have general formulae: R = H or alkanoyl Alk = alkylene (C1-3), pref. (CH2)n; n = 1, 2 or 3 Ro = mono- or dialkylamino, benzylamino, an opt. beta-monounsatd.- and/or C-alkylated morpholino, thiomorpholino-, piperazino-, N'-alkylpiperazino- or N'-(hydroxyalkyl)-piperazino group. R1 and R2 may be same or different alkyl, alkoxy, halogen, nitro or pref. H. (B) Acid addition salts of (I) with organic- and inorganic acids. |
