NEW FUNCTIONAL, HIGH-PURITY STABLE CONJUGATE OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) AND POLYETHYLENE GLYCOL WITH PROLONGED BIOLOGICAL ACTION, APPLICABLE FOR MEDICAL PURPOSES, AND BASED IMMUNOBIOLOGICAL AGENT

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to biotechnology, particularly to producing PEGylated granulocyte colony-stimulating factor (G-CSF), and is applicable in medicine. What is produced is a conjugate of G-CSF and monomethoxypolyethylene glycol attached to N-terminal methionine of the G-CSF of general formula: wherein n is integers within 681 to 1 000; m represents an integer ëÑ4; NH-G-CSF represents the granulocyte colony-stimulating factor. ^ EFFECT: produced conjugate exhibits human G-CSF activity and prolonged biological action that makes it possible to use it in pharmaceutical compositions, and as a drug preparation for preventing and treating neutropenias. ^ 17 cl, 10 dwg, 5 tbl, 21 ex