发明名称 |
Methods of cleaving DNA with rationally-designed meganucleases |
摘要 |
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
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申请公布号 |
US8143016(B2) |
申请公布日期 |
2012.03.27 |
申请号 |
US201113246263 |
申请日期 |
2011.09.27 |
申请人 |
SMITH JAMES JEFFERSON;JANTZ DEREK;HELLINGA HOMME W.;DUKE UNIVERSITY |
发明人 |
SMITH JAMES JEFFERSON;JANTZ DEREK;HELLINGA HOMME W. |
分类号 |
C12Q1/34;C07K14/00;C12N9/16;C12P21/00;C12Q1/68 |
主分类号 |
C12Q1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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