发明名称 |
Method of treating rheumatoid arthritis with antibodies to M-CSF |
摘要 |
The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells. |
申请公布号 |
US8142777(B2) |
申请公布日期 |
2012.03.27 |
申请号 |
US20070856949 |
申请日期 |
2007.09.18 |
申请人 |
HAMILTON JOHN;CAMPBELL IAN KEITH;THE UNIVERSITY OF MELBOURNE |
发明人 |
HAMILTON JOHN;CAMPBELL IAN KEITH |
分类号 |
A61K39/395;A61K31/00;A61K38/17;A61K39/00;C07K16/24;G01N33/50 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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