THIADIAZOLE DERIVATIVES AND COMPOSITIONS THEREOF AS LXR MODULATORS

摘要

The invention provides compounds of formula I, pharmaceutical compositions comprising such compounds and use of such compounds to treat or prevent a disease or disorder associated with the activity of liver X receptors (LXRs). The compound of formula I is: (see formula I) in which: n is selected from 0, 1, 2 and 3; Z is C; each Y is independently selected from -CR4= and -N=; R1 is selected from halo, cyano, hydroxyl, optionally substituted C1-6alkyl, optionally substituted C1-6alkoxy and -C(O)OR4; R4 is selected from hydrogen, cyano, hydroxyl, optionally substituted C1-6alkyl, optionally substituted C1-6alkoxy, R2 is selected from phenyl, cyclohexyl, cyclopentyl, pyrrolyl, pyrazolyl, naphthyl, benzo[1,3]dioxolyl, thienyl, furanyl and pyridyl, each of which is optionally substituted with 1 to 5 radicals; R3 is selected from phenyl, benzo[1,3]dioxolyl, pyridinyl, 2,2-difluoro-benzo[1,3]dioxol-5-yl and benzoxazolyl, each of which is optionally substituted with 1 to 5 radicals; or a pharmaceutically acceptable salt or enantiomer thereof.