发明名称 |
COMPUESTOS MALEIMIDO-FURANILO UTILES EN UN PROCEDIMIENTO GENERAL DE PREPARACION DE DERIVADOS MALEIMIDO-OLIGONUCLEOTIDO. |
摘要 |
The compounds of formula (I) substantially in exo form or salts thereof, wherein: X is a biradical selected from -(CH2)n-*, -(CH2CH2O)nCH2CH2-*, methylcyclohexyl and methylphenyl; n is an integer ranging between 1 and 30; Y is a radical selected from -COOH, a substituted phosphoramidite radical and N-hydroxysuccinimide ester (or other active ester) of carboxylic acid; and * represents the place through which X binds to Y, are useful in a general process for solid-phase preparation of maleimide-oligonucleotide derivatives.
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申请公布号 |
ES2377263(A1) |
申请公布日期 |
2012.03.26 |
申请号 |
ES20100031290 |
申请日期 |
2010.08.27 |
申请人 |
UNIVERSITAT DE BARCELONA |
发明人 |
GRANDAS SAGARRA, ANA MARIA;SANCHEZ GONZALEZ, ALBERT;PEDROSO MULLER, ENRIQUE |
分类号 |
C07D491/18;C07D207/452;C07H21/00 |
主分类号 |
C07D491/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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