The present invention relates to a novel pharmacological treatment of bacterial infectious diseases in humans. Specifically the invention relates to the use of apramycin of formula (I) or apramycin derivatives to treat bacterial infectious diseases in humans. It is demonstrated that apramycin surprisingly does not have the expected high level of toxicity observed with related aminoglycoside antibiotics but actually is even significantly less toxic than compounds already used in human medicine such as gentamicin.
申请公布号
WO2012034955(A1)
申请公布日期
2012.03.22
申请号
WO2011EP65701
申请日期
2011.09.12
申请人
UNIVERSITY OF ZURICH;ETH ZURICH;BOETTGER, ERIK;VASELLA, ANDREA