The current invention comprises a fusion polypeptide comprising a serpin-finger polypeptide conjugated to a biologically active polypeptide optionally via a peptidic linker polypeptide. Another aspect is a protein complex of the serpin-finger fusion polypeptide and a serpin, wherein the fusion polypeptide is incorporated in the serpin into the middle of beta-sheet A as strand 4a. Also an aspect of the current invention is the in vitro preparation of the protein complex. The serpin-finger polypeptide targets and anchors the biologically active polypeptide with high affinity and functional spatial orientation.
申请公布号
WO2012035034(A1)
申请公布日期
2012.03.22
申请号
WO2011EP65884
申请日期
2011.09.13
申请人
F. HOFFMANN-LA ROCHE AG;ENGH, RICHARD;KOPETZKI, ERHARD;SCHLOTHAUER, TILMAN