发明名称 |
Mutant CyaA Polypeptides and Polypeptide Derivatives Suitable for the Delivery of Immunogenic Molecules Into a Cell |
摘要 |
The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.
|
申请公布号 |
US2012071393(A1) |
申请公布日期 |
2012.03.22 |
申请号 |
US201013257569 |
申请日期 |
2010.03.23 |
申请人 |
SEBO PETER;OSICKOVA ADRIANA;MASIN JIRI;FAYOLLE CATHERINE;KRUSEK JAN;BASLER MEREK;LECLERC CLAUDE;OSICKA RADIM |
发明人 |
SEBO PETER;OSICKOVA ADRIANA;MASIN JIRI;FAYOLLE CATHERINE;KRUSEK JAN;BASLER MEREK;LECLERC CLAUDE;OSICKA RADIM |
分类号 |
A61K38/00;A61P31/12;A61P31/14;A61P35/00;C07K14/235 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|