发明名称 |
HUMANIZED ANTIBODIES TARGETING THE EC1 DOMAIN OF CADHERIN-11 AND RELATED COMPOSITIONS AND METHODS |
摘要 |
<p>The present invention relates to humanized antibodies that specifically bind an EC1 domain of a mammalian Cadherin-11 protein and compositions (e.g., pharmaceutical compositions) comprising such antibodies. The invention also relates to methods for treating Cadherin-11 -mediated disorders in a mammalian subject by administering a therapeutically effective amount of a humanized antibody of the invention. Cadherin-11 -mediated disorders suitable for treatment by the methods of the invention include inflammatory disorders (e.g., inflammatory joint disorders, such as rheumatoid arthritis), fibrosis and cancer.</p> |
申请公布号 |
WO2012009631(A8) |
申请公布日期 |
2012.03.22 |
申请号 |
WO2011US44172 |
申请日期 |
2011.07.15 |
申请人 |
SYNOVEX CORPORATION;MCARTHUR, JAMES, G. |
发明人 |
MCARTHUR, JAMES, G. |
分类号 |
A61K38/17;C07K16/28;C07K16/46 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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