发明名称 |
Methods for Treating Melanoma |
摘要 |
Methods of inhibiting melanoma tumor growth, methods of treating melanoma and metastatic melanoma, and methods of reducing the frequency of tumor initiating cells (or cancer stem cells) in melanoma tumors are described. The methods described comprise administering a DLL4 antagonist (e.g., an antibody that specifically binds the extracellular domain of human DLL4) to a subject. Related polypeptides and polynucleotides, compositions comprising the DLL4 antagonists, and methods of making the DLL4 antagonists are also described.
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申请公布号 |
US2012070438(A1) |
申请公布日期 |
2012.03.22 |
申请号 |
US201113229006 |
申请日期 |
2011.09.09 |
申请人 |
HOEY TIMOTHY C.;BEVIGLIA LUCIA;ONCOMED PHARMACEUTICALS, INC. |
发明人 |
HOEY TIMOTHY C.;BEVIGLIA LUCIA |
分类号 |
A61K39/395;A61P35/00;A61P35/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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