发明名称 |
METHODS OF USING MIRNAS TRANSCRIBED FROM THE 14Q32 REGION OF HUMAN CHROMOSOME 14 AS BIOMARKERS FOR SCHIZOPHRENIA OR SYMPTOMS THEREOF |
摘要 |
<p>Provided herein are methods for detecting a risk profile for schizophrenia or a manifestation thereof or a sub-threshold phenotype or state thereof in a subject, comprising identifying a reduction or down regulation in expression of one or more miRNAs disclosed herein, or a molecule that regulates the expression of said miRNA, in blood from the subject wherein the reduction or down regulation of expression is indicative of a risk of the subject having or developing symptoms of schizophrenia. Also provided are methods of diagnosing schizophrenia based on the expression profiles of the miRNAs and miRNA regulatory molecules disclosed herein, and methods for treating schizophrenia by modulating the expression of said miRNAs and regulatory molecules.</p> |
申请公布号 |
WO2012034189(A1) |
申请公布日期 |
2012.03.22 |
申请号 |
WO2011AU01199 |
申请日期 |
2011.09.16 |
申请人 |
NEWCASTLE INNOVATION LIMITED;CAIRNS, MURRAY;GARDINER, ERIN;BEVERIDGE, NATALIE |
发明人 |
CAIRNS, MURRAY;GARDINER, ERIN;BEVERIDGE, NATALIE |
分类号 |
C12Q1/68;A61K31/7105;A61P25/18 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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