发明名称 |
LEUKEMIA STEM CELL MARKERS |
摘要 |
The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (AML) comprising (1) measuring the expression level of human leukemic stem cell (LSC) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value; an LSC-targeting therapeutic agent for AML capable of suppressing the expression of a gene selected from among LSC marker genes or a substance capable of suppressing the activity of a translation product of the gene; a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for AML patients comprising obtaining an LSC-purged sample with at least 1 kind of LSC marker as an index; and a method of preventing or treating AML.
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申请公布号 |
US2012070450(A1) |
申请公布日期 |
2012.03.22 |
申请号 |
US201013258993 |
申请日期 |
2010.03.24 |
申请人 |
ISHIKAWA FUMIHIKO;OHARA OSAMU;SAITO YORIKO;KITAMURA HIROSHI;HIJIKATA ATSUSHI;OZAWA HIDETOSHI;SHULTZ LEONARD D.;RIKEN |
发明人 |
ISHIKAWA FUMIHIKO;OHARA OSAMU;SAITO YORIKO;KITAMURA HIROSHI;HIJIKATA ATSUSHI;OZAWA HIDETOSHI;SHULTZ LEONARD D. |
分类号 |
A61K39/395;A61K31/7088;A61K35/12;A61P35/02;C07H21/00;C07K16/18;C12N5/078;C12Q1/68;C40B30/04;G01N21/64 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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