发明名称 |
MITOCHONDRIAL ACTIVITY INHIBITORS OF CANCER-INITIATING CELLS AND USE THEREOF |
摘要 |
The present invention relates to the compounds useful in the prevention and/or treatment of tumours. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumours presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumour glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention.
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申请公布号 |
US2012071465(A1) |
申请公布日期 |
2012.03.22 |
申请号 |
US201013321379 |
申请日期 |
2010.05.20 |
申请人 |
HOPITAUX UNIVERSITAIRES DE GENEVE;UNIVERSITE DE GENEVE |
发明人 |
CLEMENT VIRGINIE;RADOVANOVIC IVAN |
分类号 |
A61K31/55;A61K31/12;A61K31/216;A61K31/352;A61K31/353;A61K31/365;A61K31/427;A61K31/4422;A61N5/00;A61P35/00;A61P35/04;C07C49/757;C07C49/84;C07C69/734;C07D213/69;C07D223/28;C07D311/22;C07D321/00;C07D417/04;C07D493/14;C12Q1/18 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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