COMPOSITIONS, METHODS AND KITS FOR DETECTING AND TREATING ALZHEIMER'S DISEASE

摘要

Compositions, kits and methods for detecting AD in a subject at an early stage include in vitro or in vivo analysis of expression of one or more markers of pre-AD. Screening platforms for identifying a therapeutic agent for preventing or treating AD in humans, and kits for detecting the presence of AD in a subject at an early stage are described herein. Compositions and methods for preventing or delaying onset of AD in a subject include a therapeutically effective amount of an inhibitor of at least one of the following proteins: an RIG-1 signaling pathway member, MDA5, VISA, RIG-1, NLRP12, and an HERV protein for inhibiting death and damage of neurons in the subject having pre-AD and a pharmaceutically acceptable carrier.