NANOPARTICLES PRODUCED FROM RECOMBINANT POLYMERS AND METHODS OF MAKING AND USING THE SAME
摘要
Described herein are nanoparticles produced from recombinant polymers. The nanoparticles are substantially uniform in size, which provides numerous advantages with respect to the delivery of bioactive agents to a subject. Methods for making the nanoparticles are also described herein. In one aspect, the nanoparticles are produced by the method comprising: a. providing a solution comprising one or more recombinant polymer in a solvent; b. forming droplets comprising the one or more recombinant polymers and the solvent; c. removing the solvent to produce the nanoparticles; and d. separating the nanoparticles based on size to produce nanoparticles that are substantially uniform in size. Finally, pharmaceutical compositions composed of the nanoparticles and methods of using the same are also described.
申请公布号
WO2011140024(A3)
申请公布日期
2012.03.22
申请号
WO2011US34907
申请日期
2011.05.03
申请人
UNIVERSITY OF UTAH RESEARCH FOUNDATION;PEASE, LEONARD, FRANKLIN, III;GHANDEHARI, HAMID;ANUMOLU, RAJASEKHAR