发明名称 |
METHODS OF USING MACROCYCLIC AGONISTS OF THE GHRELIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL MOTILITY DISORDERS |
摘要 |
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective agonists of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Such compounds are useful as medicaments for treatment and prevention of a range of medical conditions characterized by disturbed gastrointestinal motility including, but not limited to, post-surgical gastroparesis and post-operative ileus in combination with opioid-induced bowel dysfunction. These agents are effective for multiple disorders at dose levels equivalent to those required to treat a single disorder. |
申请公布号 |
US2012071412(A1) |
申请公布日期 |
2012.03.22 |
申请号 |
US201113305349 |
申请日期 |
2011.11.28 |
申请人 |
FRASER GRAEME L.;HOVEYDA HAMID R.;PETERSON MARK L. |
发明人 |
FRASER GRAEME L.;HOVEYDA HAMID R.;PETERSON MARK L. |
分类号 |
A61K38/12;A61P1/00;A61P1/04;A61P1/08;A61P29/00 |
主分类号 |
A61K38/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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