摘要 |
A method of characterizing a multi-component mixture for use in a bioprocess operation that includes providing a multi-component mixture standard with pre-determined amounts of known components; performing a Raman Spectroscopy analysis on the multi-component mixture standard; providing a multi- component test mixture from the bioprocess operation; performing a Raman Spectroscopy analysis on the multi-component test mixture; and comparing the analysis of the multi-component mixture standard and the multi-component test mixture to characterize the multi-component test mixture. In one embodiment, the multi-component mixture standard and the multi-component test mixture both comprise one or more of, at least two, at least three of, or each of, a polysaccharide (e.g. sucrose or mannitol), an amino acid (e.g., L-arginine, L-histidine or L-omithine), a surfactant (e.g. polysorbate 80) and a pH buffer (e.g., a citrate formulation). |
申请人 |
ABBOTT LABORATORIES;RAMASUBRAMANYAN, NATARAJAN;MALMBERG, LI-HONG;STERNMAN, MARTIN |
发明人 |
RAMASUBRAMANYAN, NATARAJAN;MALMBERG, LI-HONG;STERNMAN, MARTIN |