发明名称 |
TAXANE-AND TAXOID-PROTEIN COMPOSITIONS |
摘要 |
<p>Compositions comprising a taxane or taxoid, such as paclitaxel, and a protein, such as albumin or a metal-transferrin, such as gallium-transferrin, can be prepared by combining an aqueous protein solution with a second solution containing the taxane or taxoid, a non-ionic surfactant, and an alcohol; adjusting the pH of the combined solutions to between about 7.9 and about 8.3; and purifying the pH-adjusted solution to remove solutes having a molecular weight less than 10,000 Da. Such compositions can be prepared that are substantially free of non-ionic surfactants, such as Cremophor EL, and are useful in the treatment of cancers, such as breast cancer.</p> |
申请公布号 |
WO2011097149(A3) |
申请公布日期 |
2012.03.22 |
申请号 |
WO2011US23112 |
申请日期 |
2011.01.31 |
申请人 |
ONCBIOMUNE, L.L.C.;HEAD, JONATHAN, F.;ELLIOTT, ROBERT, L. |
发明人 |
HEAD, JONATHAN, F.;ELLIOTT, ROBERT, L. |
分类号 |
A61K9/00;A61K31/337;A61K47/42;A61K47/44;A61K47/48 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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