发明名称 |
Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors |
摘要 |
The present invention provides novel triazole derivatives with improved receptor activity and bioavailability properties as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular alcohol disorder; drug abuse; growth retardation; cachexia; short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; intake of rewarding food; adipogenesis; adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II; tumor cell proliferation; inflammation; inflammatory effects; gastric postoperative ileus; postoperative ileus and/or gastrectomy (ghrelin replacement therapy)". |
申请公布号 |
EP2431035(A1) |
申请公布日期 |
2012.03.21 |
申请号 |
EP20100177105 |
申请日期 |
2010.09.16 |
申请人 |
AETERNA ZENTARIS GMBH;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITY OF MONTPELLIER I;UNIVERSITY OF MONTPELLIER II |
发明人 |
AICHER, BABETTE;MUELLER, GILBERT;PAULINI, KLAUS;BLUMENSTEIN, LARS;SCHMIDT, PETER;GERLACH, MATTHIAS;TEIFEL, MICHAEL;MARTINEZ, JEAN;FEHRENTZ, JEAN-ALAIN;BLAYO, ANNE-LAURE |
分类号 |
A61K31/4196;A61P5/06;C07D401/14;C07D403/06;C07D413/14 |
主分类号 |
A61K31/4196 |
代理机构 |
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代理人 |
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地址 |
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