发明名称 |
BIOLOGICAL PACEMAKERS INCLUDING MUTATED HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNELS |
摘要 |
<p>A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated hyperpolarization-activated and cyclic nucleotide-gated (HCN) isoform to modify Ih when compared with wild-type HCN. Methods for implementing each of the biologocal pacemakers include implanting each of biologocal pacemakers into cardiac tissue.</p> |
申请公布号 |
EP2097110(B1) |
申请公布日期 |
2012.03.21 |
申请号 |
EP20070868852 |
申请日期 |
2007.11.27 |
申请人 |
MEDTRONIC, INC. |
发明人 |
SIGG, DANIEL C.;SHARMA, VINOD;XIAO, YONG-FU |
分类号 |
A61K48/00;A61K38/17;C07K14/705 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|