发明名称 |
TARGETED NITROXIDE AGENTS |
摘要 |
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation. |
申请公布号 |
EP2328875(A4) |
申请公布日期 |
2012.03.21 |
申请号 |
EP20090798808 |
申请日期 |
2009.07.17 |
申请人 |
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
WIPF, PETER;FRANTZ, MARIE, CELINE |
分类号 |
C07D235/18;A61K31/454;A61P17/18;C07D207/444;C07D263/56;C07D403/02;C07D403/04;C07D403/12;C07D403/14 |
主分类号 |
C07D235/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|