发明名称 |
PROCESS FOR SYNTHESIS OF DIARYLPYRIMIDINE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR |
摘要 |
<p>A method for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor such as etravirine is provided Typically, etravirine is synthesized by the steps of a Condensing 2,4,6-trichlorpyrimidine with 3,5-dimethyl-4-hydroxybenzonitrile to obtain compound (V), b Condensing compound (V) with 4-aminobenzonitrile to obtain compound (VI), c Ammonolysis of compound (VI) to get compound (IV), d Halogenation of compound (IV) to get etravirine.</p> |
申请公布号 |
EP2342186(A4) |
申请公布日期 |
2012.03.21 |
申请号 |
EP20100791750 |
申请日期 |
2010.06.18 |
申请人 |
EMCURE PHARMACEUTICALS LIMITED |
发明人 |
GURJAR, MUKUND KESHAV;MAIKAP, GOLAKCHANDRA SUDARSHAN;JOSHI, SHASHIKANT GANGARAM;PARDESHI, DEVISING RAMESHSING;KAMBLE, MANGESH GORAKHANATH;MEHTA, SAMIT SATISH |
分类号 |
C07D239/47;A61K31/505;C07D239/46 |
主分类号 |
C07D239/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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