<p>Non-invasive drug delivery systems useful for the absorption of therapeutically active agents through the epithelial membrane are described. The non-invasive drug delivery system delivers a therapeutic active agent with an ionizable, or ionized, metal, transition metal or metal-containing vehicle. The non-invasive drug delivery system may also have a pH adjustable vehicle which facilitates the absorption of the therapeutic agents by altering the pH of the non-invasive drug delivery system at the site of administration. Also disclosed is a method for the pH “sweeping” of the administered therapeutic active agent to provide a consistent and reproducible absorption of the active agent. Certain formulations utilize low doses of active agents without altering the active agents from their current or previous form.</p>
申请公布号
EP2429503(A1)
申请公布日期
2012.03.21
申请号
EP20100718829
申请日期
2010.05.12
申请人
PROTEIN DELIVERY SOLUTIONS, LLC
发明人
CARVER, DAVID, R.;FOHRMAN, TROY;REYNOLDS, SEAN, WILLIAM