SKIN ADHESIVE PREPARATION COMPRISING STABILIZED DONEPEZIL

摘要

[Object] The amounts of donepezil-related substances formed in a donepezil-containing adhesive preparation are reduced. [Solution] One type or two or more types of combinations of compounds selected from the groups of combinations of compounds of th efollowing (a) to (j) are blended in a donepezil-containing pressure-sensitive adhesive layer:
(a) isoascorbic acid or metal salts thereof and 2-mercaptobenzimidazole;
(b) isoascorbic acid or metal salts thereof and 2,6-di-t-butyl-4-methylphenol;
(c) isoascorbic acid or metal salts thereof and metal salts of hydroxymethanesulfinic acid;
(d) isoascorbic acid or metal salts thereof and rutin;
(e) 2-mercaptobenzimidazole and 2,6-di-t-butyl-4-methylphenol;
(f) 2-mercaptobenzimidazole and metal salts of hydroxymethanesulfinic acid; and
(g) 2-mercaptobenzimidazole and rutin;
(h) 2,6-di-t-butyl-4-methylphenol and metal salts of hydroxymethanesulfinic acid; and
(i) 2,6-di-t-butyl-4-methylphenol and rutin; and
(j) metal salts of hydroxymethanesulfinic acid and rutin.