发明名称 Methods of identifying responders to dopamine agonist therapy and treating metabolic conditions thereof
摘要 The present invention is directed to a method of identifying patients to be treated by dopamine agonist therapy comprising the step of analyzing a plasma or urine sample from said patient for concentrations of norepinephrine (NE), norepinephrine metabolites (NE metabolites), dopamine, dopamine metabolites, serotonin, serotonin metabolites, or fasting triglycerides, wherein one or more of: (a) NE metabolites, (b) NE/NE metabolites: dopamine/dopamine metabolites, (c) NE and serotonin, (d) NE/NE metabolites and serotonin, (e) NE and serotonin metabolites, (f) NE/NE metabolites and serotonin metabolites, or (g) NE is/are greater than about 30% over normal level; or dopamine/dopamine metabolites are less than about 30% below normal; or fasting triglycerides are greater than about 150 mg/dl and/or said patient has hypertension. The present invention is also directed to treating identified patients with dopamine agonist therapy.
申请公布号 US8137993(B2) 申请公布日期 2012.03.20
申请号 US201113066255 申请日期 2011.04.11
申请人 CINCOTTA ANTHONY H.;VEROSCIENCE LLC 发明人 CINCOTTA ANTHONY H.
分类号 G01N33/53;A01N43/58;A01N43/60;A01N61/00;A61K31/00;A61K31/495;A61K31/50;C12Q1/00;G01J3/42;G01J3/427;G01N13/00;G01N30/84 主分类号 G01N33/53
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