发明名称 |
Exo-selective synthesis of himbacine analogs |
摘要 |
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence: |
申请公布号 |
US8138180(B2) |
申请公布日期 |
2012.03.20 |
申请号 |
US20100827000 |
申请日期 |
2010.06.30 |
申请人 |
THIRUVENGADAM TIRUVETTIPURAM K.;SUDHAKAR ANANTHA;LIM NGIAP KIE;KWOK DAW-LONG;WU GEORGE G.;WANG TAO;HUANG MINGSHENG;GREEN MICHAEL D.;SCHERING CORPORATION |
发明人 |
THIRUVENGADAM TIRUVETTIPURAM K.;SUDHAKAR ANANTHA;LIM NGIAP KIE;KWOK DAW-LONG;WU GEORGE G.;WANG TAO;HUANG MINGSHENG;GREEN MICHAEL D. |
分类号 |
A61K31/535 |
主分类号 |
A61K31/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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