发明名称 |
Hydroxyphenyl cross-linked macromolecular network and applications thereof |
摘要 |
A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic nucleus pulposus comprises hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages. The synthetic nucleus pulposus restores or improves the water-retention capability of the disc. A method of treating an intervertebral disc with the cross-linked hyaluronan macromolecules is also provided. A method of regenerative therapy to address loss of cells of nucleus pulposus of an intervertebral disc based on treatment with the cross-linked hyaluronan macromolecules and mesenchymal stem cells is also provided. |
申请公布号 |
US8137688(B2) |
申请公布日期 |
2012.03.20 |
申请号 |
US20090380469 |
申请日期 |
2009.02.27 |
申请人 |
ZAHOS PETER A.;CALABRO ANTHONY;DARR ANIQ B.;GROSS RICHARD A.;THE CLEVELAND CLINIC FOUNDATION |
发明人 |
ZAHOS PETER A.;CALABRO ANTHONY;DARR ANIQ B.;GROSS RICHARD A. |
分类号 |
C08G63/91;A61K31/775;C08G65/48 |
主分类号 |
C08G63/91 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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