| 摘要 |
1299136 Silyl derivatives of prostaglandin UPJOHN CO 19 April 1971 [20 April 1970 2 Feb 1971] 26409/71 Heading C3S [Also in Division C2] Novel prostaglandin derivatives of the formula wherein G is C 1-4 alkyl, C 7-12 aralkyl, phenyl or phenyl substituted by 1 or 2 fluorine or chlorine atoms, or C 1-4 alkyl groups, Q is cis-vinylene or ethynylene, R 2 is C 1-4 alkyl substituted with 0 to 3 fluorine atoms, R 4 is H or C 1-4 alkyl, R 1a is -Si(G) 3 , C 1-8 alkyl, C 3-10 cycloalkyl, C 7-12 aralkyl, phenyl, phenyl substituted by 1 to 3 chlorine atoms or C 1-4 alkyl groups, or ethyl substituted in the #-position with 3-chlorine, 2 or 3 bromine or 1, 2 or 3 iodine atoms, n is 1 to 4 and A is C 1-10 alkylene, substituted with 0 to 2 fluorine atoms, and with 1 to 5 carbon atoms between COOR 1a and Q are prepared by silylating the corresponding dihydroxy acids or esters thereof. |
