发明名称 |
MODIFIED RETINOID COMPOUNDS AND THEIR USES |
摘要 |
A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group and the resulting modified retinoids are described. The method comprises the step of esterifying the carboxyl group of the retinoid with a highly sterically hindered compound, which is preferably a secondary or tertiary alcohol. The resulting retinoid esters are rendered much less toxic than the starting or parent retinoid. This process provides a retinoid ester analog of reduced toxicity so that it may be administered orally with minimal side effects and with a much greater therapeutic window. The modified retinoid compounds are useful in the treatment and prophylaxis of all diseases and disorders where retinoid compounds have been shown effective.
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申请公布号 |
CA2513583(C) |
申请公布日期 |
2012.03.20 |
申请号 |
CA20042513583 |
申请日期 |
2004.01.16 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, HECTOR F.;CLAGETT-DAME, MARGARET;GOWLUGARI, SUMITHRA |
分类号 |
C07C403/20;A61K8/67;A61K31/203;A61K31/215;A61K31/575;A61P17/10;A61P35/00;A61Q19/00;A61Q19/08;C07C69/76;C07C233/65;C07D311/30;C07D333/38;C07J9/00 |
主分类号 |
C07C403/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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