发明名称 TREATMENT OF LUPUS TARGETING THE MACROPHAGES OR THE FOLATE RECEPTOR
摘要 The invention relates to a method of treating lupus erythematosus. In one embodiment, the method comprises the step of administering to a patient suffering from lupus erythematosus an effective amount of a composition comprising a conjugate or complex of the general formula L-X where the group L comprises a ligand capable of binding to activated macrophages or other stimulated immune cells, and the group X comprises an immunogen, a cytotoxin, or another compound capable of altering macrophage function. In another embodiment, the method comprises the step of administering to a patient suffering from lupus erythematosus an effective amount of a composition comprising a conjugate of the general formula L-X where the group L comprises a vitamin, or a vitamin-receptor binding analog or derivative thereof, and the group X comprises an immunogen, a cytotoxin, or another compound capable of altering macrophage function.
申请公布号 CA2524441(C) 申请公布日期 2012.03.20
申请号 CA20042524441 申请日期 2004.05.06
申请人 PURDUE RESEARCH FOUNDATION 发明人 LOW, PHILIP STEWART;VARGHESE, BINDU
分类号 A61K47/48;A61K51/04;A61P37/00 主分类号 A61K47/48
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