发明名称 |
PROCESS FOR PREPARING VORICONAZOLE |
摘要 |
Optically pure voriconazole can be prepared in a high yield by a) subjecting 1-(2,4-difluorophenyl)-2(1H-1,2,4-tri-azol-1-yl) ethanone to Reformatsky-type coupling reaction with a substituted thiopyrimidine derivative to obtain a desired (2R,3S)/(2S,3R)-enantiomeric pair; b) removing the thiol derivative from the enantiomer to obtain racemic voriconazole; and c) isolating the racemic voriconazole by way of optical resolution using an optically active acid.
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申请公布号 |
CA2695359(C) |
申请公布日期 |
2012.03.20 |
申请号 |
CA20082695359 |
申请日期 |
2008.08.04 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
MOON, YOUNG HO;LEE, MOON SUB;YOO, JAE HO;KIM, JI SOOK;KIM, HAN KYONG;CHOI, CHANG JU;CHANG, YOUNG KIL;LEE, GWAN SUN |
分类号 |
C07D403/06;C07D239/38 |
主分类号 |
C07D403/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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