| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention refers to two-layer tablet containing a compartment comprising a pharmaceutically acceptable compound of simvastatin; and a simultaneously separate compartment containing a compound of lisinopril and a pharmaceutically acceptable compound of folic acid as active ingredients. Preferentially, the tablet is prepared by using either direct compression technique, or wet granulation technique. The two-layer tablet under the invention is applied for purposes of preventing cardiovascular disturbances, including apoplexy and paralysis accompanying diseases and complications including those related with the age of 55 and older, stenocardia, fits, atherosclerosis, Charcot syndrome, diabetes, coronary disease, peripheral vessel disease, abnormal thrombocyte function, hemodialysis, hypercholesterolemia, hypertension, myocardial infarction, congestive cardiac failure, ischemia, nephropathy, high blood plasma homocysteine level, cardiac arrest or restenosis, diseases and complications associated with smoking, obesity and sedentary life-style causing a high risk of cardiovascular diseases in individuals, including apoplexy and paralysis. ^ EFFECT: preparing an effective drug for treating cardiovascular diseases. ^ 28 cl, 3 dwg, 2 tbl, 5 ex |
