METHOD FOR CONCENTRATING NATIBE O-ANTIGEN Vibrio cholerae

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to a technology of medical immunobiological preparations, and concerns a method for concentrating a native O-antigen Vibrio cholerae. Substance of the invention involves concentrating the native O-antigen Vibrio cholerae with the use of a membrane with nominal molecular weight cut-off 500 kDa in cross-flow filtration at pressure 0.24-0.26 MPa, average specific filtration rate (792) dm3/m2/h. ^ EFFECT: ensured higher processing rate and decreased O-antigen loss by 40% with maintained quality parameters of the preparation. ^ 3 ex, 3 tbl