PROCESS FOR PREPARATION OF FLUORINATED TRIAZOLE COMPOUND

摘要

The present invention discloses a process for the preparation of 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide of Formula (I), comprising regioselective cycloaddition of 2,6-difluorobenzyl halide of Formula (II), wherein X is chloride, bromide or iodide; with a compound of Formula (IX); in which R is -COOR1, wherein R1 is hydrogen, C1-C4 linear or branched alkyl group, or-CN, or-CONH2 or -CH2OR2j wherein R2 is hydrogen or hydroxyl protecting group; in presence of an azide, Cu(I) species and a catalyst.