| 发明名称 |
DELIVERY OF PROTEINS ACROSS POLAR EPITHELIAL CELL LAYER |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide bioactive conjugates. <P>SOLUTION: The bioactive conjugates include: (1) a cell recognition moiety that binds to α<SB POS="POST">2</SB>macroglobulin receptor (α<SB POS="POST">2</SB>-MR) and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as an immunogen to invoke an immune response and (c) does not have ADP ribosylating activity. The bioactive conjugates are useful in methods of transporting the bioactive moiety across a polar epithelial membrane. Thus, this invention provides methods for parenteral administration of proteins without injection. <P>COPYRIGHT: (C)2012,JPO&INPIT |
| 申请公布号 |
JP2012051939(A) |
申请公布日期 |
2012.03.15 |
| 申请号 |
JP20110254351 |
申请日期 |
2011.11.21 |
| 申请人 |
USA GOVERNMENT;GENENTECH INC |
发明人 |
FITZGERALD DAVID J;MRSNY RANDALL J;MCKEE MIRIAM;DAUGHERTY ANN |
| 分类号 |
A61K47/46;C12N15/09;A61K9/08;A61K9/12;A61K9/14;A61K9/20;A61K9/48;A61K38/00;A61K38/21;A61K38/27;A61K38/28;A61K39/395;A61K45/00;A61K47/26;A61K47/42;A61K47/44;A61K47/48;A61P3/10;A61P31/00;A61P37/02;C07K14/21;C07K16/18;C07K19/00 |
主分类号 |
A61K47/46 |
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