发明名称 |
STAPHYLOCOCCUS AUREUS LEUKOCIDINS, THERAPEUTIC COMPOSITIONS, AND USES THEREOF |
摘要 |
Disclosed herein are isolated and purified Staphylococcus aureus bi-component leukocidin, referred to herein as LukAB, and its components LukA and LukB, antibodies specific to LukA, antibodies specific to LukB, therapeutic compositions containing LukA and/or LukB, or anti -LukA and/or anti-LukB antibodies, uses of the compositions to treat acute inflammatory conditions or S. aureus infection, methods for identifying inhibitors of LukAB-mediated cytotoxicity of human phagocytes, and methods for using LukAB as a marker to predict severity of S. aureus infection. |
申请公布号 |
WO2011140337(A3) |
申请公布日期 |
2012.03.15 |
申请号 |
WO2011US35354 |
申请日期 |
2011.05.05 |
申请人 |
NEW YORK UNIVERSITY;TORRES, VICTOR, J.;DUMONT, ASHLEY, L. |
发明人 |
TORRES, VICTOR, J.;DUMONT, ASHLEY, L. |
分类号 |
A61K39/395;A61K38/16;A61K38/17;A61P17/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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