| 发明名称 |
COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY |
| 摘要 |
The present invention relates to compounds with activity as BACE1 and NF&kgr;B modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds. |
| 申请公布号 |
US2012064099(A1) |
申请公布日期 |
2012.03.15 |
| 申请号 |
US201113094504 |
申请日期 |
2011.04.26 |
| 申请人 |
LANDRY DONALD W.;KIM TAE-WAN;DENG SHI XIAN;GONG GANGLI;HWANG JEREMY C.;XIE YULI;LIU YIDONG;RINDERSPACHER K. ALISON;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
LANDRY DONALD W.;KIM TAE-WAN;DENG SHI XIAN;GONG GANGLI;HWANG JEREMY C.;XIE YULI;LIU YIDONG;RINDERSPACHER K. ALISON |
| 分类号 |
A61K39/00;A61K31/47;A61K31/542;A61P25/28;A61P29/00;A61P35/00;A61P37/02;C07D215/36;C07D513/04;C12N5/02 |
主分类号 |
A61K39/00 |
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