发明名称 |
SIGNAL TRANSDUCTION PROTEIN TAB2 |
摘要 |
A novel signal transducer TAB2 which acts as an adapter molecule of TRAF6 and TAK1 and mediates the activation of TAK1 in the signal transduction of IL-1 was isolated. TAB2 induced the activation of NF-&kgr;B and JNK by IL-1. The signal transduction by IL-1 was inhibited by inhibiting the signal transduction of TAB2 with the use of a dominant negative mutant of TAB2. A compound inhibiting the signal transduction in TAB2 is useful as an anti-inflammatory drug. |
申请公布号 |
US2012064084(A1) |
申请公布日期 |
2012.03.15 |
申请号 |
US201113278850 |
申请日期 |
2011.10.21 |
申请人 |
MATSUMOTO KUNIHIRO |
发明人 |
MATSUMOTO KUNIHIRO |
分类号 |
A61K39/395;A61K38/00;C07K14/47;C07K16/18;C12N1/19;C12N5/16;C12N15/12;C12Q1/48;G01N33/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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