发明名称 |
POLYIONIC TRANSITIONAL METAL PHOSPHORESCENT COMPLEX/POLYMER HYBRID SYSTEMS FOR BIOIMAGING AND SENSING APPLICATIONS |
摘要 |
A new technique to stabilize transition metal phosphors in a wide variety of stimuli-sensitive polymers and gels is disclosed herein. Other than stabilization in stimuli sensitive/biocompatible matrix some of these transition metal based phosphors are also shown to act as phosphorescent crosslinkers that physically or chemically crosslink polymeric chains to form micro/nanoparticles. The microspheres/nanospheres of the present invention show decreased size and photoluminescence enhancement with particularly high sensitization at physiological pH and temperature. The so formed phosphorescent micro/nanospheres are useful for biological or environmental applications including biological labeling, imaging, and optical sensing. The techniques in the present invention enable usage of imaging agents and sensors at very low concentrations and also minimize or eliminate the usage of toxic chemical crosslinkers typically used to synthesize polymeric micro/nanoparticles.
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申请公布号 |
US2012065614(A1) |
申请公布日期 |
2012.03.15 |
申请号 |
US201113228947 |
申请日期 |
2011.09.09 |
申请人 |
OMARY MOHAMMAD A.;HU ZHIBING;MARPU SREEKAR;UNIVERSITY OF NORTH TEXAS |
发明人 |
OMARY MOHAMMAD A.;HU ZHIBING;MARPU SREEKAR |
分类号 |
A61K31/66;A61K31/675;A61K31/722;A61K47/48;A61K49/00;A61M37/00;A61P35/00;B82Y15/00;C12Q1/02;G01N21/75 |
主分类号 |
A61K31/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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