CELLS, NUCLEIC ACID CONSTRUCTS, CELLS COMPRISING SAID CONSTRUCTS AND METHODS UTILIZING SAID CELLS IN THE TREATMENT OF DISEASES

摘要

The present invention relates to cells capable of expressing IDO, nucleic acid constructs for expression of IDO, cells comprising said constructs and methods of utilizing said cells in the treatment of diseases. In particular the present invention relates to cells which expresses IDO in the absence of exposure to IFN-gamma, and to their use in preparation and/or generation of immunomodulatory cells specific for an antigen.