| 摘要 |
A series of quaternary piperazinium salts including a structure of formula (I) or (II) are provided. In formula (I) or (II), RX represents a mineral acid, an organic acid or a commercial drug containing a carboxyl moiety selected from a group consisting of the statins, the fibric acid derivatives for lowering blood lipid, the NSAIDs, the anti-asthmatic drug, the anti-diabetic drug and the prostacyclin, which can be ionically bonded with piperazine moiety. The quarternary piperazinium salts of KMUP compounds can be used as prodrugs and have multiple therapeutic functions. |
