发明名称 |
Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith |
摘要 |
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide. |
申请公布号 |
US2012065330(A1) |
申请公布日期 |
2012.03.15 |
申请号 |
US201113282129 |
申请日期 |
2011.10.26 |
申请人 |
ROBERTS MICHAEL J.;FANG ZHIHAO;NEKTAR THERAPEUTICS |
发明人 |
ROBERTS MICHAEL J.;FANG ZHIHAO |
分类号 |
C07K1/113;C07K14/00;A61K47/48;C07K14/555;C08G65/333;C08G65/334 |
主分类号 |
C07K1/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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