| 摘要 |
The present invention relates to a method for diagnosing or distinguishing, in a subject having left ventricular hypertrophy, if the subject has physiological left ventricular hypertrophy or suffers from pathological left ventricular hypertrophy, the method comprising the steps of a) determining the amounts of at least one marker selected from necrosis markers, at least one marker selected from cardiac function markers and at least one marker selected from inflammatory markers, in at least one sample of said subject, b) comparing the thus determined amounts of the said markers as determined in step a) to suitable reference amounts, and c) diagnosing if the subject is physiologically healthy or suffering from pathological left ventricular hypertrophy. The present invention also relates to a method which allows to distinguish (diagnose), in a subject suffering from pathological left ventricular hypertrophy, if the subject suffers from hypertrophic non-obstructive cardiomyopathy, hypertrophic obstructive cardiomyopathy or pressure overload hypertrophy, comprising the steps of a) determining the amounts of at least one marker selected from cardiac function markers, at least one markers selected from necrosis markers, and at least one marker selected from inflammatory markers, in at least one sample of said subject, b) comparing the amounts to reference amounts, and c) distinguishing between the different forms of hypertrophic cardiomyopathy, depending on the results of step b). In preferred embodiments of this method of the present invention, the ratio of 2 markers in formed. Optionally, as a further marker PlGF is measured. Moreover, the present invention relates to a device and a kit adapted to carry out the method of the present invention. Use of BNP (NT-proBNP), troponin T or I, GDF- 15 and PlGF for distinguishing, in a subject having left ventricular hypertrophy, if the subject has physiological left ventricular hypertrophy or suffers from pathological left ventricular hypertrophy. |
