发明名称 |
TREATMENT OF AUTOIMMUNE INFLAMMATION USING MIR-155 |
摘要 |
The present disclosure relates to the finding that microRNA-155 plays a role in the development and activity of CD4+ T cells. CD4+ T cell development and function, particularly TH17 and TH1 T cell development, can be modulated by delivery of microRNA-155 (miR-155) or antisense miR-155 to target CD4+ cells or precursor cells. In some embodiments, antisense miR-155 is used to reduce tissue specific autoimmune inflalmmation and to treat autoimmune disease. In addition, miR155 and antisense miR-155 can be used to modulate expression of cytokines from dendritic cells.
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申请公布号 |
US2012064122(A1) |
申请公布日期 |
2012.03.15 |
申请号 |
US201113230695 |
申请日期 |
2011.09.12 |
申请人 |
BALTIMORE DAVID;O'CONNELL RYAN M.;KAHN DANIEL |
发明人 |
BALTIMORE DAVID;O'CONNELL RYAN M.;KAHN DANIEL |
分类号 |
A61K31/7088;A61P1/00;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P31/00;A61P31/04;A61P31/12;A61P37/00;A61P37/04;C12N5/0783;C12N5/0784 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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