发明名称 |
PROCESS FOR PRODUCTION OF RADIOACTIVE FLUORINE-LABELED ORGANIC COMPOUND |
摘要 |
<p>Provided is a process for production of [ 18 F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for production of a radioactive fluorine-labeled organic compound, which comprises:
a deesterification step of retaining, in a reverse-phase column, a compound represented by Formula (1):
wherein R 1 is a linear or branched C 1 -C 10 alkyl chain or an aromatic substituent; and R 2 is a protecting group; charging the column with an alkaline solution to deesterify the compound, and subsequently discharging the alkaline solution from the column to obtain a compound represented by Formula (2):
wherein X is sodium or potassium; and
a deprotection step of deprotecting the amino-protecting group of the compound obtained in the deesterification step to obtain a compound represented by Formula (3):</p> |
申请公布号 |
EP2017258(B1) |
申请公布日期 |
2012.03.14 |
申请号 |
EP20070742894 |
申请日期 |
2007.05.07 |
申请人 |
NIHON MEDI-PHYSICS CO., LTD. |
发明人 |
HAYASHI, AKIO;KUROSAKI, FUMIE;TOYAMA, MASAHITO;SHINMURA, TOSHIYUKI;KANEKO, EMI |
分类号 |
C07C227/18;C07B59/00;C07C227/20;C07C229/48 |
主分类号 |
C07C227/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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