发明名称 |
Spiro-oxindole compounds and their uses as therapeutic agents |
摘要 |
This invention is directed to spiro-oxindole compounds of formula (I):
wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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申请公布号 |
EP2428515(A1) |
申请公布日期 |
2012.03.14 |
申请号 |
EP20110009687 |
申请日期 |
2006.04.11 |
申请人 |
XENON PHARMACEUTICALS INC. |
发明人 |
CHAFEEV, MIKHAIL;CHOWDHURY, SULTAN;FRASER, ROBERT;FU, JIANMIN;KAMBOJ, RAJENDER K.;HOU, DUANJIE;LIU, SHIFENG;BAGHERZADEH, MEHRAN SEID;SVIRIDOV, SERGUEI;SUN, SHAOYI;SUN, JIANYU;CHAKKA, NAGASREE;HSIEH, TOM;RAINA, VANDNA |
分类号 |
C07D498/10;A61K31/404;A61P29/00 |
主分类号 |
C07D498/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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