This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
申请公布号
EP2344648(A4)
申请公布日期
2012.03.14
申请号
EP20090816967
申请日期
2009.09.26
申请人
TOCAGEN INC.
发明人
GRUBER, HARRY, E.;JOLLY, DOUGLAS;PEREZ, OMAR;LOGG, CHRISTOPHER, R.